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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1995 1
1998 1
2001 1
2002 4
2003 1
2004 1
2005 2
2006 1
2007 2
2008 2
2011 1
2012 4
2013 3
2014 2
2015 5
2016 2
2017 4
2018 5
2019 3
2020 2
2021 1
2022 3
2023 2
2024 1

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51 results

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Page 1
Nociceptor neurons affect cancer immunosurveillance.
Balood M, Ahmadi M, Eichwald T, Ahmadi A, Majdoubi A, Roversi K, Roversi K, Lucido CT, Restaino AC, Huang S, Ji L, Huang KC, Semerena E, Thomas SC, Trevino AE, Merrison H, Parrin A, Doyle B, Vermeer DW, Spanos WC, Williamson CS, Seehus CR, Foster SL, Dai H, Shu CJ, Rangachari M, Thibodeau J, V Del Rincon S, Drapkin R, Rafei M, Ghasemlou N, Vermeer PD, Woolf CJ, Talbot S. Balood M, et al. Nature. 2022 Nov;611(7935):405-412. doi: 10.1038/s41586-022-05374-w. Epub 2022 Nov 2. Nature. 2022. PMID: 36323780 Free PMC article.
As compared with wild-type CD8(+) T cells, Ramp1(-/)(-) CD8(+) T cells were protected against exhaustion when co-transplanted into tumour-bearing Rag1-deficient mice. Single-cell RNA sequencing of biopsies from patients with melanoma revealed that intratumoral RAMP1-expres …
As compared with wild-type CD8(+) T cells, Ramp1(-/)(-) CD8(+) T cells were protected against exhaustion when co-transplanted into tumour-be …
Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response.
Sethi V, Kurtom S, Tarique M, Lavania S, Malchiodi Z, Hellmund L, Zhang L, Sharma U, Giri B, Garg B, Ferrantella A, Vickers SM, Banerjee S, Dawra R, Roy S, Ramakrishnan S, Saluja A, Dudeja V. Sethi V, et al. Gastroenterology. 2018 Jul;155(1):33-37.e6. doi: 10.1053/j.gastro.2018.04.001. Epub 2018 Apr 7. Gastroenterology. 2018. PMID: 29630898 Free PMC article.
However, depletion of gut microbiome did not reduce tumor growth in Rag1-knockout mice, which lack mature T and B cells. Flow cytometry analyses demonstrated that gut microbiome depletion led to significant increase in interferon gamma-producing T cells with corresponding …
However, depletion of gut microbiome did not reduce tumor growth in Rag1-knockout mice, which lack mature T and B cells. Flow cytomet …
Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition.
Silginer M, Papa E, Szabó E, Vasella F, Pruschy M, Stroh C, Roth P, Weiss T, Weller M. Silginer M, et al. Acta Neuropathol Commun. 2023 Mar 13;11(1):41. doi: 10.1186/s40478-023-01527-8. Acta Neuropathol Commun. 2023. PMID: 36915128 Free PMC article.
Synergy is lost when such experiments are conducted in immunodeficient Rag1(-/-) mice, and, importantly, also when Met gene expression is disrupted in the tumor cells. ...Several of these mediators are positively regulated by transforming growth factor (TGF)-beta, and pSMA …
Synergy is lost when such experiments are conducted in immunodeficient Rag1(-/-) mice, and, importantly, also when Met gene expressio …
Loss of secreted gelsolin enhances response to anticancer therapies.
Lim KHJ, Giampazolias E, Schulz O, Rogers NC, Wilkins A, Sahai E, Strid J, Reis e Sousa C. Lim KHJ, et al. J Immunother Cancer. 2022 Sep;10(9):e005245. doi: 10.1136/jitc-2022-005245. J Immunother Cancer. 2022. PMID: 36162919 Free PMC article.
Here, we investigated the effects of loss of sGSN on various anticancer therapies that are thought to induce cell death and provoke an immune response to cancer. We compared WT (wildtype) with Rag1(-/-) , Batf3(-/-) , Clec9a(gfp/gfp) , sGsn(-/-) or sGsn(-/-) Clec9a(gfp/gfp …
Here, we investigated the effects of loss of sGSN on various anticancer therapies that are thought to induce cell death and provoke an immun …
Building a healthy mouse model ecosystem to interrogate cancer biology.
Devlin R, Roberts E. Devlin R, et al. Dis Model Mech. 2022 Sep 1;15(9):dmm049795. doi: 10.1242/dmm.049795. Epub 2022 Sep 13. Dis Model Mech. 2022. PMID: 36098988 Free PMC article.
In a recent study, Sargent et al. characterise several novel Rag1-/- mouse strains and demonstrate that genetic background strongly influences xenograft development and phenotype. ...Furthermore, careful re-introduction of biological variation, be that through outbred popu …
In a recent study, Sargent et al. characterise several novel Rag1-/- mouse strains and demonstrate that genetic background strongly i …
p21 Prevents the Exhaustion of CD4+ T Cells Within the Antitumor Immune Response Against Colorectal Cancer.
Thoma OM, Naschberger E, Kubánková M, Larafa I, Kramer V, Menchicchi B, Merkel S, Britzen-Laurent N, Jefremow A, Grützmann R, Koop K, Neufert C, Atreya R, Guck J, Stürzl M, Neurath MF, Waldner MJ. Thoma OM, et al. Gastroenterology. 2024 Feb;166(2):284-297.e11. doi: 10.1053/j.gastro.2023.09.017. Epub 2023 Sep 19. Gastroenterology. 2024. PMID: 37734420 Free article.
In mouse models of CRC, p21-deficient Th1 cells show signs of exhaustion, where an accumulation of effector/effector memory T cells and CD27/CD28 loss are predominant. Immune reconstitution of tumor-bearing Rag1(-/-) mice using ex vivo-treated p21-deficient T cells with pa …
In mouse models of CRC, p21-deficient Th1 cells show signs of exhaustion, where an accumulation of effector/effector memory T cells and CD27 …
ReMixT: clone-specific genomic structure estimation in cancer.
McPherson AW, Roth A, Ha G, Chauve C, Steif A, de Souza CPE, Eirew P, Bouchard-Côté A, Aparicio S, Sahinalp SC, Shah SP. McPherson AW, et al. Genome Biol. 2017 Jul 27;18(1):140. doi: 10.1186/s13059-017-1267-2. Genome Biol. 2017. PMID: 28750660 Free PMC article.
Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.
Efremova M, Rieder D, Klepsch V, Charoentong P, Finotello F, Hackl H, Hermann-Kleiter N, Löwer M, Baier G, Krogsdam A, Trajanoski Z. Efremova M, et al. Nat Commun. 2018 Jan 2;9(1):32. doi: 10.1038/s41467-017-02424-0. Nat Commun. 2018. PMID: 29296022 Free PMC article.
Here, we elucidate the impact of evolutionary and immune-related forces on editing the tumor in a mouse model for hypermutated and microsatellite-instable colorectal cancer. Analyses of wild-type and immunodeficient RAG1 knockout mice transplanted with MC38 cells reveal th …
Here, we elucidate the impact of evolutionary and immune-related forces on editing the tumor in a mouse model for hypermutated and microsate …
Enhanced colorectal cancer metastases in the alcohol-injured liver.
Mohr AM, Gould JJ, Kubik JL, Talmon GA, Casey CA, Thomas P, Tuma DJ, McVicker BL. Mohr AM, et al. Clin Exp Metastasis. 2017 Feb;34(2):171-184. doi: 10.1007/s10585-017-9838-x. Epub 2017 Feb 6. Clin Exp Metastasis. 2017. PMID: 28168393
This work evaluated tumor cell colonization in the alcoholic host liver using a novel preclinical model of human CRC liver metastases. Immunocompromised Rag1-deficient mice were fed either ethanol (E) or isocaloric control (C) diets for 4 weeks prior to intrasplenic inject …
This work evaluated tumor cell colonization in the alcoholic host liver using a novel preclinical model of human CRC liver metastases. Immun …
51 results